Moreover, recent studies have shown that GPNMBand VCAM-1 are associatedwith age-related diseases such as Alzheimer’s disease, Parkinson’sdisease, and age-related neurodegeneration.33,34 With further development, these antibodies may be promising therapycandidates for such aging-related diseases. The gene discussed is VCAM1; the disease is early-onset autosomal dominant Alzheimer disease.