Another study found that a mixture of two bergamot-derived flavonoids, brutieridin and melitidin (BMF), acts as a non-toxic inhibitor of mevalonate metabolism and 3-hydroxy-3-methylglutaryl-CoA-reductase (HMGR) in the breast cancer cell lines T47D and MCF7, effectively reducing aldehyde dehydrogenase activity and mammosphere formation. This evidence concerns the gene HMGA1 and breast cancer.