In this study, we show that, in non-demented individuals, the predicted brain-age delta is associated with specific AD biomarkers (amyloid-β PET, CSF Aβ42 and CSF pTau) and risk factors (APOE genotype), as well as with unspecific neurodegeneration biomarkers (plasma NfL), and markers of cerebrovascular disease (WMH volume). This evidence concerns the gene APOE and cerebrovascular disorder.