In each cohort, we studied the associations of brain-age delta with biomarkers of AD pathology (CSF Aβ and p-tau as continuous values, as well as categorized in AT stages), the APOE-ε4 genotype which is the main genetic risk factor for AD, neurodegeneration (CSF and plasma NfL), and small vessel disease (White Matter Hyperintensities [WMH]). Here, APOE is linked to Alzheimer disease.