Along with the polymers assembling into nanoparticles, these hitched PROTACs molecules were easily hitchhiked on the nanoparticles, followed by get‐off in virtue of the tumor biomarkers such as intercellular highly expressed GSH[25] and cathepsin B.[26] Whereas it was found that the conjugated PROTACs molecules were difficultly liberated to initial formation totally, and these processes were also time‐consuming and compromised their enzyme‐like activity,[25] partly accounting for their auxiliary roles in tumor immunometabolic intervention and photodynamic therapy. The gene discussed is CTSB; the disease is neoplasm.