Finally, the results of the in vivo tumor transplantation experiments in nude mice revealed that the knockdown of U3 alone or overexpression of ZBTB7A significantly inhibited the growth of IDH1WT GBM tumors and prolonged the survival of nude mice; Compared with the knockdown of U3 or overexpression of ZBTB7A alone, a simultaneous knockdown of U3 combined with the overexpression of ZBTB7A significantly inhibited IDH1WT GBM tumors growth, minimized the size of IDH1WT GBM tumors, and prolonged the survival period. The gene discussed is ZBTB7A; the disease is glioblastoma.