Like for other progeroid conditions such as PYCR1 inactivation in De Barsy syndrome, this RAF1 loss‐of‐function phenotype provides another illustration of how genes that are hijacked in the context of cancer may inversely cause premature aging when inactivated (Reversade et al, 2009; Ding et al, 2020). The gene discussed is PYCR1; the disease is cancer.