STAT3 and cancer: MPS1i-treated cancer cells have also been occasionally found to escape immune-mediated clearance (Wang et al., 2021), but another study further found that cancer cells respond to CIN ultimately by triggering IL-6-STAT3 signaling (Hong et al., 2022) that protect from CIN-induced cell death, minimize interferon-related anti-cancer responses, and allow cells to adapt to CIN- and aneuploidy-induced stresses.