Altogether, these results support three conclusions: (1) the increase in survival attributed to anti-SIRPα supports the idea that CD47 modulates therapeutic outcome even during CIN; (2) the increase in survival attributed to anti-Tyrp1 highlights the importance of IgG opsonization; (3) the high success from the combination emphasizes macrophages playing a key role in achieving complete rejection and clearance. The gene discussed is TYRP1; the disease is cervical squamous intraepithelial neoplasia.