Of the genes associated with the IL-7Rαlow EM CD8+ T cells and AD (based on the 3 publicly available AD datasets evaluated), PADI4, which encodes peptidyl arginine deiminase 4 and is related to chromatin organization and protein citrullination by converting arginine residues to citrulline residues, was found to be differentially expressed among the three clinical groups though adjusted P-values from post-hoc multiple comparison testing did not reach statistically significant levels of differences in gene expression between clinical groups (Figure 3B). This evidence concerns the gene PADI4 and Alzheimer disease.