IRF1 and Alzheimer disease: We also included 9 genes which were previously identified by our group to be differentially expressed in IL-7Rαlow EM CD8+ T cells and the most highly associated with chronological aging as we previously reported (referred to as top IL-7Rαlow aging genes), and two inflammatory control genes (IRF1 and NLRX1) from IL-7Rα and non-IL-7Rα, respectively, which were not found in the AD or memory datasets though they have the potential to affect AD pathology (15, 24).