Agents shown to increase cancer cell antigen presentation include hydroxychloroquine (by autophagy inhibition) 24, poly(I:C) (by NF-κB activation downstream of dsRNA sensing) 26, SMAC mimetics (by NF-κB activation) 27, CDK4/6 inhibitors (by activation of endogenous genomic retroviral elements)25 , and others. This evidence concerns the gene CDK4 and cancer.