In order to understand how the magnitude of the association between our mediator (CRP) and our outcome (incident dementia) changed with different sets of confounders, we fitted four sequential regression models: an unadjusted model, a demographic model (adjusted for age, gender, education, APOE-ε4 allele status, and survey wave), a behavioral model (demographic adjusted model, and smoking status, alcohol consumption, and body mass index), and a chronic condition model (behavioral adjusted model, and chronic conditions). Here, CRP is linked to dementia.