Elevated CRP levels are associated with chronic conditions including cardiovascular disease and adverse cognitive status.28–36 Some research has shown that non-Hispanic Black women have the highest levels of CRP in comparison to non-Hispanic White women and men, and even non-Hispanic Black men.37–39 Circulating levels of CRP have been associated with higher white matter hyperintensity,40 Alzheimer’s disease,35 and all-cause dementia,41 albeit in studies of homogeneous populations that differ from the racial demographic composition of the United States. The gene discussed is CRP; the disease is early-onset autosomal dominant Alzheimer disease.