Apart from these point mutations that result in congenital encephalopathies with neurodevelopmental outcomes, Munc13-1 variants are also reported in sporadic amyotrophic lateral sclerosis (ALS) (F556L), frontotemporal dementia (FTD) and schizophrenia (M1296I) patients (Fromer et al., 2014; Placek et al., 2019; Pottier et al., 2019; Brown et al., 2022; Figure 4I). The gene discussed is UNC13A; the disease is frontotemporal dementia.