Pan et al. (2022) mapped a mutation in the gene encoding Methyltransferase-like 23 (METTL23) in a familial case of normal tension glaucoma. That research group demonstrated the possible significance of this mutation by demonstrating that mice overexpressing or lacking in Mettl23 develop glaucoma-like phenotypes in the absence of elevated IOP. Yu at el. report that the acetylation of p53 may lead to a reduction in Bax/Bcl-2 interaction, and ultimately apoptosis, in RGCs (Yu H. et al., 2022). This evidence concerns the gene METTL23 and low tension glaucoma.