The downregulation of NADPH oxidase 1 (NOX1) expression in the hippocampus supports this hypothesis of improved resistance to hypoxic injury, as genetic deletion or inhibition of NOX1 reduces ischemic lesions, preserves BBB integrity (Kahles et al., 2010), reduces ROS production (Coyoy et al., 2008), and reduces the extent of neuronal degeneration after stroke (Choi et al., 2015). The gene discussed is NOX1; the disease is Stroke.