Therefore, combining RORα ’s role in regulating circadian rhythms, oxidative stress and inflammation (Jarvis et al., 2002; Boukhtouche et al., 2006b; Hu et al., 2015), all key comorbidities in NDDs, with its role in cerebellar development, we hypothesize that RORα has a major causative role in NDD pathophysiology. Here, RORA is linked to Neurodevelopmental delay.