Similar data were obtained in the pancreatic Pan-02 syngeneic model in which the combination of IOA-244 with anti-PD-1 showed a greater effect on the reduction of tumor growth compared with anti-PD-1 alone with 4 of 10 animals showing an improvement in the response and 1 of 10 showing a complete tumor regression (Fig. 4J and K). Here, PDCD1 is linked to neoplasm.