ENTPD2 and hepatocellular carcinoma: Overexpression of nucleoside triphosphate diphosphate hydrolase 2 (ENTPD2) is an indicator of poor prognosis in HCC, Chiu DK et al. found that in HCC, ENTPD2 converts extracellular ATP into 5′-AMP, prevents myeloid-derived suppressor cells (MDSC) differentiation, promotes MDSC maintenance (31), and allows HCC cells to escape immune surveillance (32), but it has not been reported in gastric cancer.