BRAF and melanoma: By creating an immunodeficient variant of the 8HUM mouse line, where theRag2 locus is deleted, we extended work to xenografts with the BRAF mutant human melanoma cell line, A375.Figure 2 shows change in total mean tumour volume following s.c injection of A375 cells injected into both flanks of adult female 8HUM_Rag2-/- mice.