Studies used variant animal models of cerebral ischemia to examine ischemia-induced functional changes at different time points and the role of AQP4 in brain edema after IS and found that the inhibition of AQP4 reduced cerebral edema and improved motor recovery and long-term prognosis (Hirt et al., 2017; Liu et al., 2017). Here, AQP4 is linked to brain ischemia.