SLC6A3 and Parkinson disease: Kitta et al. (2006) have found significant brain activations in the periaqueductal gray, cerebellar vermis, supplementary motor area, putamen, insula, and thalamus during detrusor overactivity with positron emission tomography (PET) scanning in nine male PD patients. A 123I-FP-CIT SPECT study involving 31 untreated PD patients indicated PD-OAB individuals had lower striatal DAT availabilities (Mito et al., 2018). An alteration in brain raphe nuclei positioning was reported by Walter et al. (2006) in a cohort of PD-OAB patients using transcranial sonography.