Fmr1-knock out (KO) mice present hyperactivity, repetitive behavior, seizure, and social impairments as well as altered anxiety, thus recapitulating FXS symptoms of humans (Bakker et al., 1994; Spencer et al., 2005; Mineur et al., 2006; Olmos-Serrano et al., 2011; Pietropaolo et al., 2011; Rotschafer et al., 2012; Dolan et al., 2013; Qin et al., 2015). This evidence concerns the gene FMR1 and Anxiety.