SERPINA3 and neurodegenerative disease: In addition to this, based on evidence from Aimée C. Jones, SLC14A1 is involved in regulating the inflammation of microglial cells and neuron-like cells and is associated with neurodegenerative disease pathogenesis (42); Serpin peptidase inhibitor, clade A (alpha-1-antiproteinase, antitrypsin), member 3 (SERPINA3) is a secreted serine protease inhibitor.