Using mouse models of inflammation-induced gastric cancer, a study reported that at least 20% of CAFs are derived from MSCs of bone marrow, and show the expression of α-SMA, wingless-related integration site 5α (Wnt5α), IL-6, bone morphogenetic protein 4 (BMP4), and DNA hypomethylation. The gene discussed is BMP4; the disease is gastric cancer.