PFKFB3 and cancer: In addition, overexpression of TIGAR in cancer cells induces a glycolytic phenotype in CAFs and promotes the expression of HIF-1 α, PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) and lactate dehydrogenase-A along with increasing glucose uptake [Figure 2C][134].