APRIL can bind to BCMA more avidly than to BAFF, and both can induce BCMA downstream signals to PI3K-PKB/Akt (i.e., phosphoinositide-3-kinase-protein kinase B/Akt), to RAS/MAPK (i.e., rat sarcoma/mitogen-activated protein kinase), and also to NF-κB (i.e., nuclear factor kappa-B), inducing increased plasma cells proliferation and survival[31,33-37]. This evidence concerns the gene AKT1 and sarcoma.