POU5F1 and head and neck squamous cell carcinoma: Also, the expression of Sox8 in cisplatin-resistant HNSCC cell lines is responsible for orchestrating the acquisition of the CSC phenotype via ABCG2, Sox2, Oct4, and Bmi1 expression but also resistance to therapy and activation of EMT and Wnt/β-catenin pathway, favoring tumor invasion and progression.