Interestingly, the percentage of Oct4 positive cells increases significantly after treatment with 5-FU, cisplatin, and paclitaxel[121], and increased expression of ABCC6 was associated with increased resistance to cisplatin in Oct4 overexpressing cells, indicating that this poor explored ABC transporter may be relevant to resistance acquisition in HNSCC[122]. This evidence concerns the gene POU5F1 and head and neck squamous cell carcinoma.