TSPAN1 and neoplasm: ● CSCs and cisplatin resistant HNSCC overexpress the TSPAN1 gene and protein● in vitro, TSPAN1 inhibition decreased autophagy and EMT traits, induced apoptosis, increased sensibility to chemotherapy and inhibited the pSrc-signaling cascade● in vivo, TSPAN1 depletion impaired tumor growth and metastasis spreading