PGP and cancer: The hypersensitivity effects of resistant P-gp-overexpressing cancer cells upon verapamil treatment were reported (e.g., based on disrupted energy homeostasis upon ATP depletion), which might lead to enhanced anticancer activity combined with other active drug candidates such as 2A-C (but not 2F) compared with their activity against related cell lines without (overexpressed) P-gp transporter[27].