CGAS and myelodysplastic syndrome: Constitutive innate immune activation is a pathogenetic driver of ineffective hematopoiesis and MDS, in particular through the NLRP3 inflammasome[148,149] Recent studies found that the inflammasome can be induced by gene mutations involving mRNA splicing by induction of cyclic GMP-AMP synthase/stimulator of IFN genes (cGAS/STING)[150].