SAR405, a highly potent small-molecule inhibitor of the phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)/Vps34, induces a blockage at the late endosome-lysosome step autophagy flux and shows interesting preclinical efficacy in FLT3-ITD AML [Table 1][140,141]. The gene discussed is PIK3C3; the disease is acute myeloid leukemia.