The induction of apoptosis in NSCLC cells resulted in the stimulation of the caspase-3 signaling pathway, which was identified by a decrease in levels of the anti-apoptotic proteins Bcl2 and Bcl-xL, increase in the pro-apoptotic signals Bax and Bad, and elevated levels of death receptors[123]. The gene discussed is CASP3; the disease is non-small cell lung carcinoma.