Bcl-2 overexpression inhibited TRAIL-induced Bax activation, loss of MOMP, and cleavage of caspase-8 into p43/p41 and p18 active fragments, cleavage of Bid, and processing of the caspase-3 p20 fragment into the p17/p12 active fragments in SH-EP neuroblastoma cells[58]. The gene discussed is CASP3; the disease is neuroblastoma.