A study on epithelial-mesenchymal transition (EMT) showed that high expression of cFLIPs in the exogenous region caused resistance to apoptosis triggered by TRAIL, and deletion of cFLIPs was sufficient to overcome TRAIL resistance in carcinoma cell lines; when ML327 (an isoxazole-based small chemical) was induced into an immortalized mouse mammary epithelial cell line, there was a partial reversal of TGF-β-induced EMT[45]. This evidence concerns the gene CFLAR and carcinoma.