A graphene-based co-delivery nanosystem composed of graphene oxide, a PEG linker, and a furin-cleaved peptide encapsulated with TRAIL and doxorubicin (Dox) resulted in the efficient release of TRAIL and Dox to their sites of action by digesting the peptide linker by furin with the increased expression of death receptors in lung and colon adenocarcinoma cells[105]. The gene discussed is TNFSF10; the disease is colon adenocarcinoma.