TNFSF10 and colon carcinoma: The hydrophobic drug curcumin (Cur) encapsulated into the inner core of biodegradable poly (e-caprolactone)-poly (ethylene glycol)-poly (e-caprolactone) nanoparticles with TRAIL protein (TRAIL-Cur-NPs) was evaluated for their efficacy to treat HCT116 human colon carcinoma cells.