TNFSF10 and hepatocellular carcinoma: Due to the stimulation of calmodulin-dependent protein kinase II, SP1, and calcium signaling, SP94-LCPP NPs carrying TRAIL pDNA dramatically enhanced TRAIL expression and triggered TRAIL-mediated cytotoxicity in human (Hep3B, JHH-7) and murine (HCA-1) HCC cells.