In another study, DR5-B, a receptor-selective TRAIL variant, caused independent internalization of DR5; the comparison of the kinetics of TRAIL-mediated internalization and subsequent DR4 and DR5 recycling in sensitive (HCT116 and Jurkat) and resistant (HT-29 and A549) tumor cell lines of various origins revealed that TRAIL stimulated DR4 and DR5 receptor internalization in a dose-related manner. This evidence concerns the gene TNFRSF10B and neoplasm.