The comparison of six cell lines of human breast cancer (SKBR3, MDA-MB-468, MCF7, MDA-MB-231, T47D, and BT474) treated with recombinant human TRAIL (rhTRAIL) and antibodies against death receptor 4 (DR4) and death receptor 5 (DR5) for the apoptotic response showed the loss of expression of DR4 and DR5 in some cell lines that accounted to their antibody resistance. This evidence concerns the gene TNFRSF10A and breast carcinoma.