In another study, RNA interference-mediated silencing of CARPs resulted in H460 human lung cancer cell sensitization to death ligands due to activation of caspases; caspase-8 and -10 cleavage in reaction to the ligands were elevated in H460 cells after CARP-1 or -2 siRNA treatment and TNF-α/cycloheximide or TRAIL exposure[47]. Here, TNFSF10 is linked to lung cancer.