Hyaluronic acid (HA)-decorated polyethylenimine-poly(D,L-lactide-co-glycolide) (PEI-PLGA) nanoparticle (NP) (also known as HA/PPNP) with gambogic acid (GA) and TRAIL plasmid (pTRAIL) showed synergistic effects against breast cancer cells. This evidence concerns the gene TNFSF10 and breast cancer.