TNFSF10 and central nervous system cancer: The co-culturing of plasmid human TRAIL-laden nanoparticles (NPs/pTRAIL)-engineered hADSCs with patient-derived malignant glioma xenograft cells (D-270 MG) resulted in significant apoptosis and death in glioma cells (compared to controls) through an increase in levels of caspase-8 and the caspase cascade[131].