TNFSF10 and pancreatic ductal adenocarcinoma: The sensitization to TRAIL is attributed to increased levels of DR5 and dysregulation of the MAPK pathway[71]; c-Rel, an NFkB subunit regulates TRAIL-induced apoptosis in pancreatic ductal adenocarcinoma cells and transfection with siRNA against c-Relinduced apoptosis in TRAIL-resistant cells[72].