The sequencing results have shown that GC can be divided into microsatellite instability-high (MSI-H) GC, microsatellite-stable (MSS) tumor, genomically stable, or mesenchymal subtype groups based on phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) hot spot mutations (E542K, E545K, and H1047R) (7). The gene discussed is PIK3CA; the disease is neoplasm.