For example, circAKT3 is significantly overexpressed in cisplatin (CDDP)-resistant GC tissues and cells and eliminates the inhibition of miR-198 to activate the PI3K/AKT signaling pathway in GC cells, leading to CDDP-based DNA-damaging chemotherapy resistance (9) (Figure 1; Supplementary Table S1). Here, PIK3CA is linked to gastric cancer.