HIF-1 is a key transcriptional activator that mediates the adaptive response of the organism to hypoxia, which regulates gene expression through changes in intracellular oxygen concentration and exerts an influential role in tumor cell hypoxia adaptation, energy metabolism, tumor angiogenesis, and invasion and metastasis, with its expression of HIF-1 closely related to invasive metastasis of lung cancer (Hua et al., 2020). The gene discussed is HIF1A; the disease is lung carcinoma.