Further publications pointed out that hypoglycemia with a similar biochemical profile may also occur in a subset of patients with other PI3K-AKT pathway disorders caused by (mosaic) activating mutations in AKT3, PIK3CA, PIK3R2, and CCND2, thus suggesting that this type of metabolic dysregulation is in principle shared by the entire group of disorders (43, 44). This evidence concerns the gene PIK3CA and Hypoglycemia.