Heterozygous mutations of CACNA1C, which is expressed in the Cav1.2 (α1C-containing) Ca2+ channels can cause a variety of disorders with cardiac arrhythmias as the leading symptom (Timothy syndrome, Brugada syndrome, Long-QT syndrome) with distinct genotype-phenotype correlations. Here, CACNA1C is linked to chronic obstructive pulmonary disease.