EIF2S3 encoding a subunit of the eukaryotic translation initiation factor 2, eIF2γ, and hemizygous mutations have been associated with a more severe syndrome of developmental delay/intellectual disability, epilepsy, hypogonadism, microcephaly, and obesity (MEHMO syndrome, OMIM #300148). This evidence concerns the gene EIF2S3 and obesity due to melanocortin 4 receptor deficiency.