POMC and neoplasm: The analysis of CD patients data revealed that both NR3C1 and NR3C2 expression levels were negatively correlated with morning plasma ACTH levels (Spearman R = -0.3326; p = 0.0052 and R= -0.3717; p = 0.0017, respectively) and tumor size (Spearman R = -0.3345; p = 0.0053 and R = -0.4194; p = 0.0004, respectively) (Figures 2A, B).