We analyzed the relationship between the expression of NR3C1, NR3C2, GR and MR with clinical and pathomorphological features: morning ACTH level, morning cortisol level, midnight cortisol level, 24h UFC, clinical remission in CD patients, tumor size, invasive growth status, USP8/USP48 mutation status, granulation pattern (sparsely granulated (SG) vs densely granulated (DG)) and Ki-67 score. This evidence concerns the gene USP48 and neoplasm.