Another study based on transgenic obese mice models with a mutation in a pleiotropic protein prohibitin (PHB) showed the development of obesity in both sexes regardless of the type of diet and the development of T1D-like phenotype in males on a high-fat diet only, related to mononuclear cell infiltration in the pancreas, and insulitis (61). Here, PHB1 is linked to obesity due to melanocortin 4 receptor deficiency.