To further understand this relationship in NEPC versus ADCA, we examined the gene network correlation between ZBTB7A and genes that negatively regulate cell cycle such as CDKN1A, RB1 and TP53. All three gene networks were highly associated with ZBTB7A in ADCA samples as indicated by their correlation coefficient of close to 1.0 (Figure 2D). The gene discussed is RB1; the disease is autosomal dominant cerebellar ataxia.