Due to the limited NEPC models, we took advantage of the fact that small-cell neuroendocrine carcinomas (SCNC), including small-cell lung cancer (SCLC), and NEPC share similar genomic characteristics, such as RB1 deletion and TP53, mutation independent of the tissue of origin (14, 16–18). This evidence concerns the gene TP53 and small cell lung carcinoma.