As an oncogene in other cancers, ZBTB7A promoted tumorigenesis via suppression of the p14ARF-MDM2-p53 pathway and activation of NF-κB, TGF-β and the PI3K/AKT pathway leading to increased cell proliferation, metastasis, chemoresistance and inhibition of apoptosis (28–32). Here, ZBTB7A is linked to cancer.