In addition, HMGB1 plays multiple roles in the inflammatory response in DN; some studies have reported that HMGB1 plays an important role in the development of DN, lupus nephritis, ANCA-associated vasculitis kidney damage, acute kidney injury and interstitial nephritis (55, 56). The gene discussed is HMGB1; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.