Taohong Siwu Decoction is composed of Persicae Semen, Angelicae Sinensis Radix, Carthami Flos, Chuanxiong Rhizoma, Rehmanniae Radix Praeparata and Paeoniae Radix Alba, which can reduce the level of HMGB1, alleviate insulin resistance and reduce inflammation in T2DM patients (87). Here, HMGB1 is linked to Insulin resistance.