Although, in vitro experiment validated FAM83A expression in tumorigenic PC tissues and in silico analysis propose a novel AL049555.1/hsa−miR−129−5p/FAM83A axis in tumorigenesis and reveal the axis-related immune microenvironment status in patients with PC, our results will need to be validated in a large independent cohort. Here, SACK1A is linked to pachyonychia congenita.