Notably, FAM83A upregulates tetraspanin 1 (TSPAN1) through the WNT-CTNNB1 signaling pathway and affects macroautophagy/autophagy, suggesting that FAM83A and its target axis may predict prognosis and become a novel therapeutic target for patients with PC (21). The gene discussed is SACK1A; the disease is pachyonychia congenita.