SMAD2 and cardiac hypertrophy: The difference in cardiac hypertrophy responses of Tgfbr1/2 and Smad2 and Smad3 (Smad2/3) specific cardiac fibroblasts deficient mice to pressure overload stimulation indicates that atypical TGF-β signal also plays an effective role in cardiac fibroblast-mediated remodeling after chronic injury (166).