At the same time, HG can also regulate the expression of Methyl CpG binding protein 2 (MeCP2), resulting in the methylation of target gene promoter inhibiting the expression of ras association domain family 1 isoform A (RASSF1A) and extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, thus triggering cardiac fibroblasts proliferation and DCM (86). The gene discussed is MAPK3; the disease is familial dilated cardiomyopathy.