Our data demonstrated thata distinct fatty acid signature comprising high levels of myristic acid (C14:0),palmitoleic acid (C16:1),oleic acid (C18:1n-9C),cis-vaccenic acid (C18:1n-7), and homo-gamma-linolenic acid (C20:3n-6) is particularly associated with insulin-related metabolic risk in women with PCOS, independent of BMI. Here, INS is linked to polycystic ovary syndrome.