In line with this observation, the reduction of CASR expression in PAds-derived cells blunted the pERK inhibition induced by GlaOC and GluOC, confirming that in parathyroid tumor cells pERK/ERK modulation by GlaOC and GluOC is mainly mediated by CASR activation. Here, EIF2AK3 is linked to tumor of parathyroid gland.