Shared features between osteocytic and neuronal connectivity have been demonstrated.(68) Moreover, osteocyte transcriptome signature is enriched for genes regulating neuronal network formation, suggesting this program is important in osteocyte communication.(69)TBC1D24 mutation causes dominant hearing loss.(70) These DEGs (EGR1, FAF1, H3F3B, PAN2, RNF213, SAMD4A, and TBC1D24) we found at 6 hours post‐culture suggest that osteocytes not only orchestrate osteoclastic bone resorption and osteoblastic bone formation, but also chondrogenesis and angiogenesis in response to mechanical loading. The gene discussed is RNF213; the disease is hearing loss disorder.