LRP5 and craniodiaphyseal dysplasia: Following uniform Gene Ontology terminology, LRP6 HBM would fit within the subgroup 24 that includes LRP5 HBM, sclerosteosis (types 1 and 2), van Buchem disease, craniodiaphyseal dysplasia, and several other heritable disorders that involve dysregulation of WNT signaling.(34)