SOST and hyperostosis corticalis generalisata: HBM, van Buchem disease (OMIM # 239100),(30) and sclerosteosis types 1 and 2 (OMIM #269500, #614305),(30) all considered “endosteal hyperostoses,” have in common a pathogenesis that involves deficient inhibition of bone formation by sclerostin.(3, 4)