There remains a particular continued need for therapies that increase long bone cortical bone mass given that existing osteoporosis therapies, such as PTH analogues, typically have a more robust effect on vertebral bone over long bones.(55) Thus, ALDH2 gene therapy could be used to mitigate the detrimental effects on quality of life and the financial burden as both a prophylactic and therapeutic treatment for bone loss caused by chronic alcohol use with ALDH2 deficiency. The gene discussed is PTH; the disease is hyperinsulinemic hypoglycemia, familial, 4.