ALDH2 and Osteopenia: To determine if AAVrh.10hALDH2 could reverse established osteopenia in ALDH2‐deficient mice, Aldh2E487K+/+ mice were treated with AAVrh.10hALDH2 or AAVrh.10control (1011 gc) or PBS by intravenous administration 6 weeks after beginning ad libitum ethanol in the drinking water, and then ethanol was continued for an additional 12 weeks (Fig. 1A).