TNFRSF13C and inflammation of heart layer: These findings indicate the possible development of fibrosis as a late abnormalcy of severe carditis which might develop as sequelae to KD.33 Also, a set of five genes are candidates as biomarkers for KD diagnosing, namely, the HLA-DQB1, HLA-DRA, ZBTB48, TNFRSF13C, and CASD1.34