In addition to endothelial and cancer associated fibroblasts cell types classified above, we used “Single R” package to identify several other distinct clusters, they were b-cell Naïve, epithelial-cells bladder, epithelial-cells bronchial, monocyte, monocyte:CD14+, monocyte:CD16+, NK cell, CD4+ central memory T cell, CD4+ central effector T cell and tissue-stem-cells:BM_MSC:BMP2 (Figure 7C). Here, CD4 is linked to cancer.