In the rats KOA model established by Papain Enzyme, after DHJST intervention, the swelling volume of the right hind foot of the rats was significantly reduced, and the levels of IL-1β, IL-6, and TNF-α in synovial fluid of the knee joint were downregulated, meantime the expression of NLRP3, ASC, Caspase-1, p-NF-κB-P65, and p-IκBa in the synovium of the knee joint was decreased, and the pathological changes such as synovitis and cartilage degeneration of the knee joint were alleviated. Here, TNF is linked to synovitis.