CASP1 and synovitis: In the rats KOA model established by Papain Enzyme, after DHJST intervention, the swelling volume of the right hind foot of the rats was significantly reduced, and the levels of IL-1β, IL-6, and TNF-α in synovial fluid of the knee joint were downregulated, meantime the expression of NLRP3, ASC, Caspase-1, p-NF-κB-P65, and p-IκBa in the synovium of the knee joint was decreased, and the pathological changes such as synovitis and cartilage degeneration of the knee joint were alleviated.