Expression levels of 11 CRGs were significantly up-or downregulated in SD, including ATP7A, ATP7B, SLC31A1, FDX1, PDHA1, PDHB, GLS, CDKN2A, DBT, GCSH, and LIAS, indicating that CRGs play a significant role in the development of SD. The gene discussed is FDX1; the disease is Salla disease.