TTN and neoplasm: In immune infiltration analysis, these four genes showed a significant association with most immune cells, and in previous studies, TTN is a frequently mutated gene in BLCA and can be used as a biomarker to predict immune response (Zhu et al., 2020); ARID1A is a component of the SWIth/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, and its function is to control many important biological processes, such as tumor microenvironment regulation and anticancer immunity (Conde and Frew, 2022; Lu et al., 2022), presenting a significant association with the expression of immune cells.