By extending the test using a multi-gene panel, we found an additional 8% mutations in different susceptibility genes, such as MUTYH, CHEK2, ATM, NBN, BRIP1, and TP53 involved in several hereditary cancer syndromes (Desmond et al., 2015; Tsaousis et al., 2019; N; Tung et al., 2015). The gene discussed is BRIP1; the disease is Inherited cancer-predisposing syndrome.