POLE and breast cancer: On the other hand, 46 patients (8%), namely 33/423 (8%) with BC, 3/59 (5%) with OC and 10/64 (16%) with PC harbored germline PVs/LPVs in other cancer susceptibility genes, as follows: 17 (37%) in MUTYH, 11 (24%) in CHEK2, 4 (9%) in ATM, 3 (6%) in RAD51C and TP53, 2 (4%) PALB2, BRIP1, and NBN. In addition, a single PV in POLE, MSH2, and RAD51D was detected in two patients (Table 2).