S100A8 and colorectal carcinoma: Moreover, our study revealed that the expression levels of the 11 hub ARGs were closely related to immune cell infiltration; S100A8 and TBC1D10C expression levels were positively correlated with the macrophage M1 immune filtrating level in CRC tissues whereas NFKB1 expression levels were negatively correlated with the level of infiltrating Tregs.