NFKB1 and colorectal carcinoma: In addition, the interleukin (IL)-17 signaling pathway plays a tumorigenic role in CRC and is associated with the activation of nuclear factor κ-light-chain-enhancer of activated B (NF-κB) cells and mitogen-activated protein kinases (MAPKs), which upregulate the survival pathways required for the growth and development of tumor cells (Wang et al., 2014).