Moreover, NAMPT is overexpressed in CRC tissues and is associated with a poor prognosis by stabilizing the protein components of Smad2, Smad3, and Smad4 in the TGF-β signaling pathway, thereby increasing the activity of the TGF-β signaling (Lv et al., 2021). The gene discussed is SMAD4; the disease is colorectal carcinoma.