Figure 8 is a schematic representation of the floated p53 activation; Table 5 corroborates the scope provided in the Figure 8 by indicating that cell death is downregulated when osteoblast proliferation is initiated. The latter reflects p53’s down-regulatory function achieved when the processes enhancing proliferation are down-scaled. In addition, the upregulation of p53 directly antagonizes the activity of SLC7A11 (Liu et al., 2022). The direct antagonism of SLC7A11 enhances ferroptosis in osteosarcoma (Table 6). This evidence concerns the gene SLC7A11 and osteosarcoma.