TP53 and neoplasm: Several studies (Velletri et al., 2016; Luo et al., 2018; Hatina et al., 2019; Lu et al., 2020; Usman et al., 2020; Sciot, 2021; Magri et al., 2021) have reported the direct modulation of target genes and the effects of mutant-p53 in the tumor development process.