TP53 and cancer: Figure 1 illustrates the roles of p53 in atypical and typical ferroptosis in the course of osteosarcoma. TP53 mediates the expression of SLC7A11C in human cancers, and Liu et al. have clarified crucial elements concerning the roles of p53 in regulating atypical and typical ferroptosis in osteosarcoma (Liu et al., 2020).