Table 5 summarizes the different mechanisms reported by individual studies. The inactivation of p53 promotes the survival of tumor cells (Van Maerken et al., 2014). Leroy et al. (2017) and Pang et al. (2020) have shown that a high incidence of osteosarcoma is associated with TP53 mutation. Here, TP53 is linked to osteosarcoma.