TP53 and osteosarcoma: Several studies (Bouchalova et al., 2014; Xie et al., 2016; Gnanapradeepan et al., 2018; Babamohamadi et al., 2022; Su et al., 2022) have contended that p53 plays a central role in up-regulating atypical ferroptosis in the course of osteosarcoma through increasing the production of ROS, lipid and iron-mediated cell death, and cell proliferation (Table 4) (Liu and Gu, 2022b).