Several studies (Bouchalova et al., 2014; Xie et al., 2016; Gnanapradeepan et al., 2018; Su et al., 2022; Babamohamadi et al., 2022) have indicated that upregulation of p53 enhances atypical ferroptosis in the course of osteosarcoma, whereas other studies (Komori, 2016; Van Maerken et al., 2014; Pang et al., 2020; Saraf et al., 2018; Yang and Zhang, 2013; Leroy et al., 2017) have reported that inactivation of p53 downregulates atypical ferroptosis in osteosarcoma. Here, TP53 is linked to osteosarcoma.