Several studies (Yang and Zhang, 2013; Van Maerken et al., 2014; Komori, 2016; Saraf et al., 2018; Pang et al., 2020;; Leroy et al., 2017) have reported the regulatory mechanisms of p53 on atypical ferroptosis in the course of osteosarcoma, while inactivation of the gene inhibits cell proliferation. The gene discussed is TP53; the disease is osteosarcoma.