Twenty-seven HCC-specific TFs were listed in the TiED database, including ARID3A, BACH1, BATF, BCL11A, CEBPB, CTCFL, EGR1, ESR1, FOS, FOXA1, FOXA2, GATA1, GATA2, GATA3, HNF4A, HNF4G, IRF4, MAFF, MAFK, MTA3, MYBL2, MYC, PAX5, RUNX3, TEAD4, TFAP2A, and TFAP2C. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.